The HSP70 Sequence Database  


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Prokaryote HSP70 Genes

Laurence A. Moran and Blerta Kolaj


Prokaryotic HSP70 gene sequences are mostly organized according to the taxonomy of Margulis and Schwartz (1998). The NCBI classification is noted as alternative (alt.). There are many other possible classifications. Some prokaryotes have a separate page that can be reached by clicking on the species name (for example, E. coli). In most cases you can view a complete GenBank nucleotide sequence record by clicking on the accession number. The HSP70 protein ID is shown when the nucleotide sequence record contains multiple genes. Where there are multiple independent records of the same gene the most accurate and complete sequence is indicated by a red asterisk. Conflicts are often noted in SwissProt/UniProt entries. The HSP70 Sequence Database doesn't always agree with the decisions made by SwissProt annotators.

Gene ID numbers are listed whenever possible, with a link to EntrezGene. In some cases, there are multiple sequence records for the same gene but these records are not all referenced in the EntrezGene entry. Those sequence records are listed separately. In other cases, the EntrezGene entry is complete and individual nucleotide sequence files may not be listed on this page. They can be found at the bottom of the EntrezGene webpage. RefSeq records (i.e., those beginning with NC, NP, XC, and XP) are not shown if there is a known EntrezGene link for that particular gene. In the absence of an EntrezGene record the RefSeq file will be listed.

Most bacterial genes are orthologous to the dnaK gene that was first identified in E. coli. These genes should be named "dnaK" but this isn't always the case. There are multiple copies of dnaK genes in some species of cyanobacteria. These are named dnaK1, dnaK2 and dnaK3. There are other members of the HSP70 gene family in bacteria. The hscA gene is found in E. coli and Haemophilus influenzae and some other members of the gamma subdivision of Proteobacteia. It is also called hsc70 and hsc66. The E. coli genome contains a third member of the HSP70 family called hsc62. Distantly related members of the family are found in the spirochaete Borrelia burgdorferi (dnaK-1) and in the proteobacterium Myxococcus xanthus (sglK).

Note that the phylogeny of HSP70 genes does not agree with the taxonomic classification used by NCBI. The most important difference is that the archaebacterial dnaK genes are closely related to those of the Gram Positive group and do not form a separate Archaea domain.


ARCHAEA

Euryarchaeota

Ferroplasma acidarmanus Fer1 Haloarcula marismortui [alt: Halobacterium marismortus] Halobacterium sp. NRC-1 Halobacterium curtirubrum [alt: Halobacterium salinarum] Haloferax luncentense Haloferax mediterranei [alt: Halobacterium mediterranei] Haloferax volcanii DS2 Halogeometricum borinquense Haloquadratum walsbyi DSM 16790 Methanococcoides burtonii DSM6242 Methanosaeta thermophila [alt: Methanothrix thermophila] Methanosarcina acetivorans C2A Methanosarcina berkeri str. fusaro Methanosarcina mazeii Methanosarcina mazeii Goe1 Methanosarcina thermophila Methanosphaera stadtmanae DSM 3091 Methanospirillum hungatei JF-1 Methanothermobacter thermautotrophicus str. DeltaH [alt: Methanobacterium] Natronococcus occultus Natronomonas pharaonis DSM 2160 Picrophilus torridus DSM 9790 Thermoplasma acidophilum Thermoplasma volvanium uncultured methanogenic archaeon RC-I


EUBACTERIA

DIVISION FIRMICUTES

Thermogotae (anoxygenic thermophiles) [incl. Aquifales]

Thermogota maritima MSB8 Aquifex aeolicus Aquifex pyrophilus

Deinococci [alt: Deinococcus-Thermus]

Thermomicrobium roseum Thermus thermophilus [alt: Thermus aquaticus] Deinococcus proteolyticus Deinococcus radiodurans

Endospora (Low G+C Gram Positive Bacteria) [incl. Bacillales]

Bacillus cereus ATCC 14579 Bacillus clausii KSM-K16 Bacillus halodurans C-125 Bacillus licheniformis ATCC 14580 Bacillus sphaericus Bacillus subtilus Bacillus magaterium Brevibacillus choshinensis (strain:HPD31) Clostridium acetobutylium ATCC 824 Clostridium perfingens str. 13 Clostridium tetani E88 (causes tetanus) Clostridium thermocellum ATCC 27405 Enterococcus faecalis V583 Erysipelothrix rhusiopathiae Geobacillus kaustophilus HTA426 Geobacillus stereothermophilus [alt. Bacillus stereothermophilus] Geobacillus thermoglucosidasius [alt. Bacillus thermoglucosidasius Lactococcus lactis subsp. cremoris Lactoccus lactis subsp. lactis str. I11403 Lactobacillus acidophilus NCFM Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Lactobacillus johnsonii NCC533 Lactobacillus sakei Lactobacillus plantarum WCFS1 Listeria innocua Clip11262 Listeria monocytogenes Megasphaera elsdenii Moorella thermoacetica ATCC 39073 Oceanobacillus iheyeensis HTE831 Oenococcus oeni PSU-1 Phytoplasma from Peanut witches'-broom Ureaplasma urealyticum Staphylococcus aureus Staphylococcus epidermidis Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Staphylococcus haemolyticus JCSC1435 Streptococcus agalactiae Streptococcus mutans Streptococcus pyrogenes Streptococcus pneumoniae Streptococcus thermophilus Thermoanaerobacter tengcongensis MB4

Aphragmabacteria (mycoplasmas) [alt. Mollicutes]

Mycoplasma hominis Mycoplasma capricolum Mycoplasma florum L1 Mycoplama gallisepticum R Mycoplasma genetalium str. G37 Mycoplasma hyopneumoniae 7448 Mycoplasma mobile 163K Mycoplasma mycoides subsp. mycoides SC str. PG1 Mycoplasma penetrans HF-2 Mycoplasma pneumoniae str. M129 Mycoplasma pulmonis UAB CTIP Mycoplasma synoviae 53 Ureaplasma parvum serovar 3 str. ATCC 700970

Fusobacteria

Fusobacterium nucleatum subsp. nucleatum ATCC 25586

Actinobacteria (High G+C Gram Positive Bacteria)

Brevibacterium linens BL2 Corynebacterium diphtheriae NCTC 13129 Corynebacterium efficiens YS-314 Frankia sp Cc13 Leifsonia xyli subsp. xyli str. CTCB07 Mycobacterium avium subsp. paratuberculosis [alt: M. paratuberculosis] Mycobacterium leprae Mycobacterium tuberculosis Nocardia farcinica IFM 10152 Propionibacterium acnes Rubrobacter xylanophilus DSM 9941 Streptomyces avermitilis MA-4680 Streptomyces coelicolor Streptomyces griseus Symbiobacterium thermophilum IAM 14863 Thermobifida fusca YX Tropheryma whipplei TW08/27

Pirellulae (incl. Chlamydiae)

Chlamydia trachomatis [alt: Chlamydia muridarum] Chlamydia muridarum [alt: Clamydia trachomatis strain MoPn] Chlamydia pneumoniae [alt: Chlamydophila pneumoniae] Pirellulia marina Pirellulia staleyi Planctomyces limnophilus Planctomyces maris planctomycete str. 140 Verrucomicrobium spinosum

DIVISION GRACILICUTIS

Chlorobia (anoxygenic green sulphur bacteria)

Chlorobium limicola DSM 245 Chlorobium phacobacteriodes BS1 Chlorobium phacobacteriodes DSM 266 Chlorobium tepidum TLS Pelodictyon phaeoclathratiforme BU-1 Prosthecochloris aestuarii DSM 271 Prosthecochloris vibrioformis DSM 265

Chloroflexi (green nonsulfur phototrophs)

Dehalococcoides ethenogenes 195

Cyanobacteria

Anabaena variabilis [alt: Anabaena sp. strain PCC 7937] Anabaena sp. strain PCC 7120 [alt: Nostoc sp. strain PCC 7120] Anabaena variabilis str. ATCC 29413 [alt. Anabaena flos-aquae UTEX 1444] Aphanothece halophytica Crocosphaera watsonii WH8501 Goeobacter violaceus PCC7421 Nostoc sp. PCC7120 Nostoc punctiforme PCC 73102 Prochlorococcus marinus subsp. marinus str. CCMP1375 Prochlorococcus marinus str. MIT9313 Prochlorococcus marinus str. NATL2A Prochlorococcus marinus subsp. pastoris Synechocystis sp. strain PCC6803 Synechococcus strain PCC7942 [alt. Synchococcus elongatus PCC 7942] Synechococcus elongatus PCC 6301 Synechococcus sp. WH8102 Thermosynechococcus elongatus BP-1 Trichodesmium erythraeum IMS101 CHLOROPLAST GENES

Saprospirae [alt. Bacteriodes]

Porphyromonas gingivalis Rhodothermus marinus [alt: R. obamensis]

Spirochaetae

Borellia burdorferi Borrellia garnii PBi Leptospira interrogans Leptospira intrrogans serovar Copenhageni str. Fiocruz L1-130 Leptospira intrrogans serovar Lai str. 56601 Treponema denticola ATCC 35405 Treponema pallidum

Proteobacteria (Purple Bacteria)

Delta and Epsilon Subdivision

Bdellovibrio bacteriovirus HD100 Campylobacter jejuni Desulfotalea psychrophilia LSv54 Desulfuromonas acetoxidans DSN 684 Geobacter metallireducens GS-15 Geobacter sulfurreducens PCA Helicobacter pylori Myxococcus xanthus Syntrophobacter fumaroxidans MPOB

Alpha Subdivision

Agrobacterium tumefaciens [alt. Rhizobium radiobacter] Agrobacterium tumefaciens str. C58 [alt. Rhizobium radiobacter] Azoarcus sp. EbN1 Bartonella henselae str. Houston-1 [alt. Rochalimaea henselae] Bartonella quintana str. Toulouse [atl. Rochalimaea quintana Bordetella bronchiseptica RB50 Bordetella parapertusis 12822 Bordetella pertusis Tahama I Bradyrhizobium japonicum Bradyrhizobium japonicum str. USDA 110 Bradyrhizobium sp. WM9 Brucella ovis [alt: Brucella melitensis biovar ovis] Brucella suis 1330 Candidatus Pelagibacter ubique HTCC 1062 Caulobacter crescentus Chromobacterium violaceum ATCC 12472 Dechloromonas aromatica RCB Ehrlichia sp. HGE agent Ehrlichia canis str. Jake Ehrlichia ruminantium str. Gardel Ehrlichia ruminantium str. Welgevonden Ehrlichia sennetsu Erthrobacter litoralis HTCC2594 Magnetospirillum gryphiswaldense Mesorhizobium ciceri Mesorhizobium loti MAFF303099 Mesorhizobium sp. BNC1 Nitrobacter hamburgensis X14 Nitrobacter winogradskyi Nb-255 Novosphingobium aromaticivorans DSM 12444 Paracoccus denitrificans PD1222 Ralstonia eutropha JMP134 Rhizobium galegae Rhizobium leguminosarum Rhizobium meliloti [alt: Sinorhizobium meliloti] Rhodobacter capsulatus Rhodobacter sphaeroides 2.4.1 Rhodopseudomonas sp. No.7 Rhodopseudomonas palustris CGA009 Rickettsia akari str. Hartford Rickettsia conorii Rickettsia felis URRWXCal2 Rickettsia prowazeki Rickettsia rickettsii Rickettsia sibirica 246 Rickettsia typhis str. Wilmington Silicibacter pomeroyi DSS-3 Silicibacter sp. TM1040 Sphingopyxis alaskensis RB2256 Thiobacillus dentrificans ATCC 25259 uncultured proteobacterium Wolbachia endosymbiont strain TRS of Brugia malayi Wolbachia endosymbiont of Drosophila melanogaster Zymomonas mobilis subsp. mobilis ZM4 MITOCHONDRIAL GENES

Beta Subdivision

Burkholderia cepacia [alt: Pseudomonas cepacia] Burkholderia mallei ATCC 23344 Burkholderia pseudomallei [alt: Pseudomonas pseudomallei] Burkholderia pseudomallei 1710b Burkholderia pseudomallei K96243 Burkolderia tuberum [alt. Burkolderia sp. STM678] Methylovorus sp. Neissaria gonorrhoeae FA 1090 Neisseria meningitidis MC58 Neisseria meningitidis Z2491 Nitrosomona europaea Ralstonia metallidurans [alt: Ralstonia eutrophus CH34] Rhodoerax ferrireducens DSM 15236

Gamma Subdivision

Acinetobacter sp. ADP1 Actinobacillus (Haemophilus) actinomycetemcomitans Azotobacter vinelandii Buchnera sp. Buchnera aphidicola Buchnera aphidicola str. Sg (Schizaphis graminum) Buchnera aphidicola str. APS (Acyrthosiphm pisum) Colwellia psychrerythraea 34H Coxiella burnetii Erwinia carotovora subsp. atroseptica SCR11043 [atl. Pectobacterium atroseptica] Escherichia coli
Francisella tularensis Haemophilus ducreyi Haemophilus influenzae Rd Legionella pneumophila Legionella pneumophila str. Lens Legionella pneumophila str. Paris Legionella pneumophila subsp. pneumophila str. Philadelphia 1 Mannheima succiniciproducens MBEL55E Methylococcus capsulatus str. Bath Pasteurella haemolytica [alt: Mannheimia haemolytica] Pasteurella multocida Photobacterium profundum SS9 Photorhabdus luminescans subsp. laumondii TTO1 Pseudomonas aeruginosa Pseudomonas putida KT2440 Pseudomonas syringae pv. glycinea Pseudomonas syringae pv. phaseolicola 1448A Pseudomonas syringae pv. syringae B728a Pseudomonas syringae pv. tomato str. DC3000 Psychrobacter sp. St1 Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 Salmonella enterica subsp. enterica serovar Typhi Ty2 Salmonella typhimurium LT2 Shewanella oneidensis MR-1 Shigella flexneri 2a str.301 Shigella sonie SsO46 Vibrio cholerae Vibrio fuscherii ES114 Vibrio harveyi Vibrio parahaemolyticus RIMD 2210633 Vibrio proteolyticus Vibrio vulnificus CMCP6 Vibrio vulnificus YJ106 Xanthomonas campestris Xylella fastidiosa 9a5c Yersinia mollareti ATCC 43969 Yersinia pestis Angola Yersinia pestis biovar Medievalis str. 91001 Yersinia pestis CO92 Yersinia pestis KIM Yersinia pseudotuberculosis IP 32953

UNIDENTIFED PROKARYOTIC GENES

unidentified soil organism [U49141, dnaK fragment]
unidentified soil organism [U49142, dnaK fragment]
unidentified soil organism [U49143, dnaK fragment]
unidentified soil organism [U49144, dnaK fragment]
unidentified soil organism [U49145, dnaK fragment]
unidentified soil organism [U49146, dnaK fragment]
unidentified soil organism [U49147, dnaK fragment]
unidentified soil organism [U49148, dnaK fragment]
unidentified soil organism [U49149, dnaK fragment]
unidentified soil organism [U49150, dnaK fragment]


Laurence (Larry) A. Moran [lamoran@utoronto.ca]
[Dept. of Biochemistry][University of Toronto], Toronto ON, Canada M5S 1A8