The HSP70 Sequence Database  


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Human HSP70 Genes

Burcin Uygungil and Laurence A. Moran



These webpages are under construction. See HSPA5 for an example of the new format.


Genes

Locus

Proteins


HSPA1A
HSPA1B

Chromosome 6p21.3

HspA1, HspA2

There are two genes at this locus; HSPA1A and HSPA1B. They encode the major heat shock inducible version of the gene family. Neither of the genes have introns.

 

HSPA1L

Chromosome 6p21.3

Hsp70t

This gene is adjacent to the HSPA1A and HSPA1B genes. It encodes the testis-specific version of the gene family. The HSPA1L gene does not have introns.

 

HSPA2

Chromosome 14q24.1

Hsc70B

This gene encodes the minor constitutively exspressed version of the gene family.

 

HSPA3

[Chromosome 21?]

heat shock 70kDa protein 3???

This gene has an official HUGO name [HSPA3], an official Entrez Gene record [HSPA3], and an OMIM record [MIM 140570] but it does not exist. There is no such gene in the human genome. The false entries are due to a single mistaken mapping experiment from R. Morimoto's lab in 1987 [Harrison et al. (1987)].

 

HSPA4

Chromosome 5q31.1-q31.2

not a member of the HSP70 family

This gene has an official HUGO name [HSPA4] that refers to the protein product as "heat shock 70kDa protein 4." It is also known as "hsc70RY." The Entrez Gene entry [HSPA4] also identifies it as a member of the HSP70 multigene family, as does the OMIM entry [MIM 601113]. None of these databases are correct. This is not an HSP70 gene. It has been known since 1999 [Nononguchi et al. (1999)] that this gene actually encodes Apg-2, an HSP110 homologue. The original misidentification by Fathallah et al (1993) was based, in part, on sequencing errors but mostly on an overactive imagination.

 

HSPA5

Chromosome 9q33-q34.1

BiP, GRP78

This gene encodes BiP, the ER version of the HSP70 gene family.

 

HSPA5BP1

Chromosome 11q12.2

not a member of the HSP70 family

The original HUGO symbol for this gene was HSPA5BP1 for "heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) binding protein 1." This is a misleading name. The gene is actually a completely unrelated gene called GBP (GRP78 binding protein; i.e., a protein that binds to GRP78). The gene name resembled HSPA5 and this led to confusion. The new HUGO name is [TMEM132A] which stands for transmembrane protein 132A. (Probably the same as GBP.) The old Entrez Gene record for [HSPA5BP1] was updated to TMEM132A on May 25, 2006.

 

HSPA6
HSPA7

Chromosome 1q23.1

putative proteins Hsp70B and Hsp70B'

The HSPA6 gene is almost certainly a pseudogene. The HSPA7 gene may not exist in the human genome - it may be a variant of HSPA6.

 

HSPA8

Chromosome 11q23.3-q24.1

Hsc70

This gene encodes HSC70, the major constitutively-expressed (cognate) protein.

 

HSPA9B

Chromosome 5q31.1

mitochondrial Hsp70 (mtHsp70)

This gene encodes the mitochondrial member of the HSP70 multigene family.

 

HSPA10

 

suppressed - same as HSPA8

The HUGO record for [HSPA10] has been merged with that for HSPA8.



Laurence (Larry) A. Moran [lamoran@utoronto.ca]
[Dept. of Biochemistry][University of Toronto], Toronto ON, Canada M5S 1A8